Tuesday, 21 September, 2021


Oxford COVID Vaccine Safe, Effective, Especially in Older Adults

Covid-19 Vaccine Early results indicate AstraZeneca/Oxford vaccine is promising
Patty Aguilar | 20 November, 2020, 16:57

The phase 2 trial saw 560 participants, 240 of whom were over 70, split into groups that received either one or two doses of the vaccine, or a placebo.

Oxford scientists have worked in tandem with UK-based biopharmaceutical giant AstraZeneca on their vaccine.

The researchers said that two doses of CoronaVac at different concentrations and using different dosing schedules had goof tolerance and moderately immunogenic in healthy adults aged between 18-59 years.

A safe and effective vaccine that protects against SARS-CoV-2 infection is an important tool in controlling the global spread of the virus.

Now, researchers from the University of Oxford have released promising results from the phase II clinical trial of the vaccine candidate.

From the earlier phase data, researchers found that younger participants experienced side effects like pain at the vaccine's injection site, fever and muscle ache more often than older adults.

Maheshi Ramasamy, a consultant and co-lead investigator at the Oxford Vaccine Group hailed the preliminary results as "encouraging", but said his team needs to continue research. However, the level of antibodies generated was lower than in people who had recovered from the illness.

The Phase III trials of the ChAdOx1 nCov-2019 vaccine are ongoing, with early efficacy readings possible in the coming weeks.

Pollard said there was "no competition" with other vaccines.

"What this could mean is that in the future when we're looking to boost people's responses, we might need to do it more often in older people than we do with younger people, but we're not thinking that we're going to need to boost people a couple of times a year as we do with the flu vaccine". The incidence of adverse reactions in the 3 micrograms and 6 microgram groups were similar. There were also spike-specific T-cell responses that peaked 14 days after prime vaccination which were similar in all age and dosage groups.

"Our new study answers some questions about protecting older adults, but questions remain about effectiveness and length of protection, and we need to confirm our results in older adults with underlying conditions to ensure that our vaccine protects those most at risk of severe COVID-19 disease", Gilbert explained.

He added it was still too early to determine whether their vaccine could effectively prevent COVID-19.

Ministry of National Health Services Regulations and Coordination has sought $150 million funds from the federal government for advance booking of COVID-19 vaccines, ARY News reported on Friday.

Professor Pollard said: "We're still waiting to get to the point where we can do the analysis to just work out how well the vaccine can protect people, and we're getting ever closer to that".

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