Monday, 10 August, 2020


Russian Federation completes human trial of Covid-19 vaccine: Results promising

READ MOREIf we get a coronavirus vaccine should it be mandatory READ MOREIf we get a coronavirus vaccine should it be mandatory
Bennie Garza | 15 July, 2020, 06:24

The other players in the COVID-19 vaccine race are Gilead Sciences, Oxford University's researchers and American biotech company Moderna are at the forefront of developing a Covid-19 vaccine.

The study should run until October 27, 2022, but preliminary results should be available long before.

An investigational vaccine created to protect against coronavirus disease 2019 (COVID-19) was generally well tolerated and resulted in production of both binding and neutralizing antibodies in healthy adult volunteers, according to interim results of an ongoing phase 1 trial published today in the New England Journal of Medicine.

Trial sites will begin registering people for the trial next week, said a Moderna spokesman.

"Philanthropy has played a critical role in our efforts to fast-track an effective vaccine and help save lives across the world", co-lead of UQ's vaccine project Paul Young said.

"No matter how you slice this, this is good news", Dr Anthony Fauci, the U.S. governments top infectious disease expert, told The Associated Press news agency.

But some in the scientific community said they would reserve judgment until they saw the full results in peer-reviewed form.

According to the New England Journal of Medicine report, Phase I was conducted in 45 test subjects.

Emory's study consisted of 45 healthy adults, 18 to 55 years of age, who received two vaccinations, 28 days apart, with mRNA-1273 in a dose of 25 μg, 100 μg, or 250 μg.

The blood from seriously ill coronavirus patients on ventilators was found by researchers to be highly inflammatory and harmful to the body, the South China Morning Post reported on Wednesday citing a study by Dutch scientists. These were more likely to occur after the second dose and in people who got the highest dose. This was more common after the second vaccination, particularly at the highest dose, but none of the side effects were considered serious.

More than half of those who got the middle of three doses suffered mild to moderate fatigue, chills, headache and muscle pain. And the NIH-developed shot isn't the only one set for such massive US testing, crucial to spot rare side effects.

Amesh Adalja, an infectious diseases specialist at Johns Hopkins University, added it was encouraging that the participants developed high levels of an advanced class of antibodies.

World Health Organization said the vaccine was still in Phase-1 trials, that means it must undergo 3-4 more trials to be declared safe. In this phase, researchers try to determine whether the vaccine is able to generate the immune response that can fight with the virus in real-life situations.

The spike protein is a part of the virus it uses to invade human cells, but by itself is relatively harmless.

The advantage of this technology is that it bypasses the need to manufacture viral proteins in the lab, shaving months off the standardization process and helping to ramp up mass production. The Russian regulatory authorities would decide on the requirement of a third phase of the vaccine, the report said.

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