It contains a tiny needle made of freeze-dried compressed insulin, which is released and injected into the stomach's lining.
In tests on animals, an MIT-led research group showed they could deliver enough insulin to lower blood sugar to levels comparable to those produced by doses administered through skin. The same capsule can also be adapted to deliver other protein drugs. The shaft of the needle, which does not enter the stomach wall, is made from another biodegradable material. It involves some clever engineering to ensure it's released at exactly the right time: a tiny, spring-loaded needle is released once the sugar glass that surrounds it is dissolved by acid in the stomach.
An ingestible injection could bypass the hazards of that journey - letting insulin absorb through the wall of the stomach, said Dr. Giovanni Traverso, a gastroenterologist at Boston's Brigham & Women's Hospital and a senior author of the study. Therefore, it does not matter how the pill falls, it will always be able to orient itself to be in contact with the stomach walls. And for almost as long, researchers have pursued a way to orally administer insulin.
Scientists figured out how to hide a shot inside a pea-sized pill - creating a swallowable gadget, inspired by a tortoise shell, that can inject medicines like insulin from inside the stomach. When your body isn't making insulin correctly, you can take man-made insulin to help control your body blood sugar. "Our motivation is to make it easier for patients to take medication, particularly medications that require an injection", explained Traverso. So, they turned to an unlikely animal for inspiration: the leopard tortoise. The tortoise with a high, steep shell dome can right itself when rolling onto its back. Researchers also hope the new technology can be used to deliver many other types of medications and hormones that have been only deliverable intravenously. The pill is a variant of its shape made using computer modelling since it allows the capsule to reorient itself in the stomach.
"Also, if a person were to move around or the stomach were to growl, the device would not move from its preferred orientation", Alex Abramson, MIT graduate student and study first author, added.
The research in pigs has successfully delivered up to 5 milligrams of insulin, comparable to the amount a type 2 diabetic patients would need to inject.
Once the contents from the capsule are released, it passes through the digestive system without any side effects. The MIT team is now collaborating with Novo Nordisk for further study and product development to make it available in pharmacies at the soonest time.
Other authors of the paper include Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Morten Revsgaard Frederiksen, Andreas Vegge, Frantisek Hubalek, Jorrit Water, Anders Friderichsen, Johannes Fels, Rikke Kaae Kirk, Cody Cleveland, Joy Collins, Siddartha Tamang, Alison Hayward, Tomas Landh, Stephen Buckley, Niclas Roxhed, and Ulrik Rahbek.
Richard Neal, D-Mass., chairman of the House Ways and Means Committee, will begin hearings this week on presidential tax returns. Besides opposition from some conservatives pushing for more wall money, some liberals may not accept the final product.
Patty Mills has averaged 3.7 assists and scored 11.4 points over the last 10 games for San Antonio. 28, 2017. Durant made his first six shots and already had 15 points by the 4:28 mark of the opening quarter.
This is the third month in a row that NASA has announced a further delay for the first major test flight of Crew Dragon . NASA has once again pushed back the first test flights for its Commercial Crew program .
The rover is part of the ExoMars programme, a joint endeavour between ESA and the Russian State Space Corporation, Roscosmos. Her images of crystallized DNA fibers confirmed theories about DNA's double-helix structure.
As this feature is AI driven, Microsoft states that they will try to always keep your background blurred, but can't guarantee it. Background Blur is a feature Microsoft announced during the Ignite 2018 conference that was first added to Microsoft Teams .
The Windies have already sealed a series win over England heading into the third Test, which begins on Saturday. Cameron did not specify exactly what modification he favoured, and he is not arguing the letter of the law.
Speaking to reporters at the site, Soylu said rescue work has been ongoing for 31 hours in an effort to reach more survivors. Mr Yerlikaya also said the textile workshop on the ground floor of the building was operating without a license.
A spokesman for Toronto Police said investigators had "worked diligently" to "do everything possible to locate the missing men". McMahon also says he has no doubt McArthur would have continued to kill if he wasn't arrested by police previous year .
That's about the biggest battery I've seen on a mainstream phone, and Motorola says it should provide 3 days of battery life. In a short while after the official launch, Motorola will make the G7 Play available on Boost Mobile, Virgin Mobile, U.S.
Elizabeth Warren Announces She is Running for President in 2020
The plan, according to documents provided by the campaign, would impose a 2% tax on Americans whose net worth exceeds $50 million. She'll spend Sunday in Iowa, where the nation's leadoff caucuses will be the first test of the Democratic field's mettle.
Sumatran tiger Asim arrives at London Zoo
Keepers had hoped the big cats would breed but have been left devastated after Asim, the male they brought in, attacked Melati. Asim was recently transferred to London from a Danish safari park to serve as a new mate for female resident tiger Melati.
Saints top Rams in post-Super Bowl rankings
He also divulged that he's enjoyed a margarita or two since the game, and is planning on vacationing in Costa Rica. A game wrought with missed field goals, terrific punts and sloppy runs did little to improve the NFL's appeal.
Sprint is Suing AT&T Over Its Misleading ‘5G E’ Label
Now there's no getting around the fact that 5G E is impressively fast, but to be clear, that's not what Sprint's lawsuit is about. Sprint said it is spending billions of dollars to roll out a "true" 5G network, starting in nine cities this year, including NY .
BoE governor warns of no-deal Brexit recession risk
The BoE kept its wage forecasts largely unchanged with earnings rising by more than 3 percent a year over the next three years. Ricky Knox said: "Irrespective of whether we have a no-deal Brexit , the United Kingdom economy is slowing".