Friday, 22 February, 2019


Gum disease bug linked to Alzheimer’s (and new drug is being tested)

Research: It may be possible to restore memory function in Alzheimer's, preclinical study finds Gum disease–causing bacteria could spur Alzheimer's
Patty Aguilar | 25 January, 2019, 23:59

They also studied the enzyme's effects in the brains of mice, and found that it caused the animals to develop signs of Alzheimer's. "I'm fully on board with the idea that this microbe could be a contributing factor".

Referring to tau, a protein associated with Alzheimer's disease, Dominy told Newsweek: "Studies reported in our paper indicate that P. gingivalis and gingipains can directly kill neurons, damage tau, elevate levels of beta amyloid, and increase markers of neuroinflammation".

The study also showed that sleep disruption rapidly spreads Tau while it also causes the release of synuclein protein which leads to Parkinson's disease.

The research team, which is coordinated by pharma startup Cortexyme that was co-founded by first author Stephen Dominy, isn't claiming to have discovered definitive evidence of Alzheimer's causation. Yet. At the time, he was treating people with HIV at the University of California, San Francisco.

Professor Colin Masters AO from the Florey Institute said, "The blood test accurately predicted when members of a family with inherited Alzheimer's disease would begin to show symptoms".

"Our identification of gingipain antigens in the brains of individuals with AD and also with AD pathology but no diagnosis of dementia argues that brain infection with P. gingivalis is not a result of poor dental care following the onset of dementia or a outcome of late-stage disease, but is an early event that can explain the pathology found in middle-aged individuals before cognitive decline", the authors write in their paper. "He points out that while most of the data presented in the Cortexyme study supported their hypothesis, gingipains weren't found in all of the Alzheimer's-affected brains, 'so whilst it may be a cause, the data don't exactly support it being the only cause".

Previous research has shown options for detecting Alzheimer's disease in its early stages. That early appearance is important, Lynch says, because "you would expect it to be there before the onset" of symptoms.

However, he said the study was limited because the team has not yet determined if different strains of P. gingivalis are more virulent than others in causing brain infection. Giving mice a gingipain-inhibiting substance by mouth twice a day treated the brain infection and was better at reducing bacterial load than the antibiotic moxifloxacin (a recommended treatment for people with gingivitis).

Seeking to block Pg-driven neurotoxicity, Cortexyme set out to design a series of small molecule therapies targeting Pg gingipains.

A drug developed by the company, COR38, is now in human trials. A larger study is slated to start this year.

We don't know for sure that P. gingivalis causes Alzheimer's disease in humans, or that the drug will work.

They tested the saliva and cerebrospinal fluid (CSF), which surrounds the brain and spinal cord, of people with Alzheimer's disease, looking for presence of P. gingivalis DNA. "These are odd ideas, but they seem to be getting some traction".

Following this, scientists tested drugs in mice aimed at blocking the toxic proteins and found they were able to halt degeneration in the brain.

Tau is normally found in the brain - even in healthy people - but under certain conditions it can clump together into tangles that injure nearby tissue and presage cognitive decline. "It really will be important to see how this plays out in human randomized controlled trials, which is the gold standard for understanding whether a therapeutic targeting something like the P. gingivalis mechanism would actually be effective", she said. But he's skeptical that the bacteria or its toxin directly cause Alzheimer's.

In other words, it's unknown whether gum disease increases the risk of Alzheimer's or if people with dementia have an increased risk of gum disease because of poor oral care.

Understanding that process has revealed potential drug targets, she said, since repressive histone modification is controlled or catalyzed by enzymes. Inherited Alzheimer's is rare genetic disease. Not necessarily. But if healthy people want to stay on the safe side and potentially reduce their risk, Noble says, "the main conclusion we still have is: brush and floss".

Recommended

loading...
...

Is milk healthy? Canada's new food guide says not necessarily Is milk healthy? Canada's new food guide says not necessarily It also urges consumers to choose water over other beverages, like sugary fruit juice, pop, alcohol or flavoured milk. She points to rates of obesity, diabetes, and cardiac disease increasing, as well as rates of cancer.

General Mills recalls some Gold Medal flour over salmonella concerns General Mills recalls some Gold Medal flour over salmonella concerns Advice for consumersFood that is contaminated with Salmonella bacteria usually does not look, smell or taste spoiled. General Mills said it has not received "any direct consumer reports of confirmed illnesses related to this product".

Renault chairman and CEO Carlos Ghosn resigns from position Renault chairman and CEO Carlos Ghosn resigns from position Ghosn has denied a separate breach of trust charge over personal investment losses he temporarily transferred to Nissan in 2008. Renault executives want to resume work on a new ownership structure within the Alliance, once the new management is settled.

Michael Cohen's Lawyer Accuses Donald Trump's Attorney Rudy Giuliani of Witness Tampering Michael Cohen's Lawyer Accuses Donald Trump's Attorney Rudy Giuliani of Witness Tampering Democrats have suggested they may subpoena Cohen to compel his testimony and the committee's chairman, Democratic Rep. Elijah Cummings of Maryland, said Cohen could be brought from prison to appear before Congress.

Chelsea signing Gonzalo Higuain will boost Eden Hazard, says Danny Higginbotham Chelsea signing Gonzalo Higuain will boost Eden Hazard, says Danny Higginbotham He told Chelsea's website on completing the signing: " When the opportunity to join Chelsea presented itself I had to take it ". Higuain will take the famous #9 shirt at Chelsea, which has been somewhat of a cursed number at the club in recent memory.

Bharat teaser: Salman Khan starrer looks like a sure shot Eid blockbuster Bharat teaser: Salman Khan starrer looks like a sure shot Eid blockbuster The scene guarantees whistles in the movie theatres as Salman introduces his character and why he is called " Bharat ". In the teaser, the film-makers describe Bharat as the journey of a man and a nation together.

Kenya Marks Cervical Cancer Awareness Week Kenya Marks Cervical Cancer Awareness Week She said: "I, as a Prime Minister, can stand here and say this - I know what it's like to go through a cervical smear test". Research has revealed that fear is among the main reasons young women delay their routine smear tests .

Wealthy Trump officials keep trying to relate to furloughed workers, keep failing Wealthy Trump officials keep trying to relate to furloughed workers, keep failing Some are lining up at food banks to feed their families and struggling to make rent and mortgage payments . He urged them to seek loans from banks and credit unions to supplement their lost wages.

Houston Rockets' James Harden hits 30-point mark 21 straight games Houston Rockets' James Harden hits 30-point mark 21 straight games Harden's fast-break bucket with three seconds left tied the opponent scoring record at the Garden set by Kobe Bryant in 2009. Kenneth Faried started in just his second game since joining the Rockets on Monday, scoring 11 points.

Ocasio-Cortez, Tlaib Added to Oversight Committee Before Cohen Hearing Ocasio-Cortez, Tlaib Added to Oversight Committee Before Cohen Hearing While the New Yorker campaigned on eliminating ICE, she hasn't prioritized the proposal since her election to Congress. But the White House has frequently sought to cast the 29-year-old Cortez as a distraction.

Sheffield Wednesday's Fernando Forestieri records heartbreaking message in Emiliano Sala search Sheffield Wednesday's Fernando Forestieri records heartbreaking message in Emiliano Sala search Sounding conversational and jokey, he said he was "so scared" and: "I'm on a plane that seems like it is breaking apart". Guernsey Police have called off the search for footballer Emiliano Sala , saying chances of survival are now "remote".

Thunder clamp down on defense, top Blazers for 3rd straight win Thunder clamp down on defense, top Blazers for 3rd straight win Portland now sits in fourth-place in the Western Conference after going into Tuesday's contest tied with Oklahoma City for third. The Thunder are 5.5-point favorites against Portland . " Paul George is a great player", said Stotts.

Premier League should delay VAR implementation, says Pochettino Premier League should delay VAR implementation, says Pochettino And while Nkoudou's Tottenham career is yet to spark into life, he could be a useful option off the bench to stretch teams. But after that, it is about whether the referee sees the incident or not.

Franco-German unity is dated gauge of European Union progress Franco-German unity is dated gauge of European Union  progress The treaty stipulates France will help push for German inclusion to the five-strong permanent members of the UN Security Council. He also noted plans to increase cooperation on training and education, which could improve cross-border labor mobility.

Family kicked off flight after passengers complained about body odor Family kicked off flight after passengers complained about body odor The airline's decision prompted an argument between the family and ground crew staff that was captured by Adler on video. An American Airlines jet taxis on the runway at Washington National Airport in Washington, U.S., August 9, 2017.