Only Arsenal icon Thierry Henry and Manchester United legend Wayne Rooney had scored 150 league goals for the same club prior to Aguero's strike against the Saints.
However, Andros Townsend's equaliser and the introduction of Eden Hazard from the bench woke Chelsea from their slumber after the break and Morata restored the hosts' lead before Pedro Rodriguez sealed the three points.
Sane has so far scored three goals and provided four assists in 13 appearances for City this campaign.
Instead, City completely battered Southampton in the first-half.
They also created chances against City, though more predictably given recent times they went unconverted.
Sane, Sterling, Silva and Aguero can be seen passing the ball amongst themselves inside the Southampton area before, eventually, losing it.
They head into the Wednesday's European clash in very confident mood after picking up their ninth win of 11 in the Premier League over the weekend.
He would have known, as would the team, that they were in for a hard afternoon regardless, but that if you let City get away in the early stages then the result is a foregone conclusion.
Southampton, who had kept back-to-back clean sheets prior to today, were given a route back into the match half an hour in as Ederson raced off his line and wiped out Liverpool loanee Ings, leaving referee Lee Mason with no choice but to point to the penalty spot.
"The first season, he was scared".
But City continued to threaten, and Sane nearly made it five with a vicious left-foot shot from the edge of the area that struck the bar just after the hour.
Guardiola believes Sterling will add to his astonishing haul of 46 caps, but feels he has room to improve at the age of 23 in his bid to be rated among the world's finest players.
Sane completed an impressive individual and team display in stoppage time when he steered in a left-foot shot from 18 yards following another assist from Sterling.
They'll be kicking things off at Manchester's Etihad stadium on 1 June, before ending this at Wembley Stadium, on 15 June. British band "The Spice Girls " perform during the Closing Ceremony at the 2012 Summer Olympics, in London.
Lucas Castro and Joao Pedro will be deployed further forward, looking to provide service to central striker Leonardo Pavoletti. Juventus can now turn their attentions to the Champions League and a meeting with Manchester United on Wednesday.
Amazon has found another way to entice holiday shoppers this season: free shipping to everyone, including non-Prime members. Amazon is joining its rival retailers in beefing up its free shipping program just ahead of the holiday shopping blitz.
I was happy with bringing Ander Herrera into the game. "People watching this game will not believe how hard we worked this week". It was one of the best first-half performances we have seen in the Premier League since we have been promoted.
Publicly, the royal family has maintained its innocence and two weeks ago blamed the killing on a "rogue operation". Khashoggi, a critic of Saudi rulers, was killed inside the country's consulate in Turkey on 2 October.
Amazon released a statement on Saturday and said that the building would remain closed until further notice. One of the two men was found under debris and taken to a hospital, where he was pronounced dead.
It's safe to say that Callum Wilson has been one of the best performing English strikers in the Premier League this season. The team performed much better. "The two points we lost in the last minute against Chelsea, we got them back".
The new wave of sanctions, the second since August, will target Iran's energy , shipbuilding, shipping, and financial sectors. Rouhani insisted on state TV that Iran will "sell its oil and it will sell" despite the crippling sanctions.
The Supreme Court had issued a hunting order for T1 in September, ruling that she could be killed if tranquilisers failed. A man-eater tigress Avni was killed in Yavatmal district forest of Maharashtra , news agency ANI reported.
Roney's last England appearance came against Scotland and Hampden Park, but after the game he announced his worldwide retirement. Southgate said: "This tribute to Wayne is a unique opportunity that is befitting of our nation's record goalscorer".
The Walking Dead Movies Signs Andrew Lincoln After Show Exit
"It's not the beginning of the end, it's the end of the beginning", Andrew said on The Talking Dead after the episode aired. Fire off in the comments section and let us know where you stand on the continuation of THE WALKING DEAD universe.
Pete Davidson under fire for mocking Dan Crenshaw
Kevin Roberts in a May primary, Crenshaw faces Todd Litton, a Democrat, in the race for Texas' 2nd Congressional District. After six months of combat operations, Dan was hit by an IED blast during a mission in Helmand province, Afghanistan.
Puel hails players after emotional Leicester win
Goals from Erik Lamela, Lucas Moura and Harry Kane appeared to put Tottenham in an unassailable position at Wolverhampton. Srivaddhanaprabha bought the club for $57 million in 2010 and it was promoted to the Premier League in 2014.
Arsenal fight back for well-earned draw with Liverpool
It would be fair to say, almost three months into his first season at the Emirates, that Emery has met such expectations. Arsenal began the game on top but it was Liverpool that had the ball in the back of the net on 18 minutes.