Novo Nordisk has since 2015 been undertaking a research collaboration with Ablynx on the Nanobody platform.
The Belgian pharma company revealed that it was the second time that Novo Nordisk had approached it for a takeover proposal in the month of December 2017.
Last week, Japan's Takeda (4502.T) bid 520 million euros for Belgian cell therapy group Tigenix.
"The proposed transaction with Ablynx represents a compelling opportunity for both companies and is in the best interests of all of Ablynx's stakeholders", said Lars Fruergaard Jørgensen, chief executive officer of Novo Nordisk. It did not say why.
Ablynx specialises in the development of nanobodies: small fragments of antibodies that like larger antibodies can bind onto the antigens that cause an immune system response.
Caplacizumab, an anti-von Willebrand factor (vWF) Nanobody, is Ablynx's lead candidate meant to block the interaction of ultra-large vWF multimers (ULvWF) with platelets having an immediate effect on platelet aggregation and the micro-clots that cause severe thrombocytopenia, tissue ischemia and organ dysfunction in acquired thrombotic thrombocytopenic purpura (aTTP).
The $11 billion haemophilia market is facing upheaval and Novo stands to lose sales following approval of a new Roche drug Hemlibra. It has instead focused on its market-leading position making insulin and other diabetes treatments.
The latest offer from the Danish pharma company is €30.50 per share in cash, which includes a €2.50 per share in contingent value rights (CVR), while the first offer made in early December was €26.75 per share. The firm accounts for almost half of the global market for insulin, but is also present in other sectors such as horomone treatments and drugs to control haemophilia.
In March, the company approached Global Blood Therapeutics (GBT.O), a US biotechnology company focused on serious blood disorders, to discuss a potential takeover.
Finance chief Brandgaard said the current bid could be revised if Ablynx agreed to engage in talks.
Novo Nordisk, who has made previously unsuccessful bids for the Belgian business, announced its €2.6 billion offer on its website, Monday.
However, Novo Nordisk disclosed that Ablynx's board of directors had declined from carrying out any discussions with it, in spite of its two proposals. They closed at 21.20 euros on Friday.
"We envisage Novo needing to hike the offer and could see counterbids", the analysts said.
Ablynx's share price soared 44% on the back of the rejection.
Its products, which are all still undergoing medical trials, target many different diseases such as rheumatoid arthritis, psoriasis or cancer. We firmly believe that the combination of Ablynx's pipeline, R&D team and antibody engineering platform with Novo Nordisk's own R&D organization would create a stronger combined research base.
In addition to this, they will also build their skills and knowledge levels required to implement WLAN in a small/medium network. At the end of the course, they will also be able to resolve regular issues with EIGRP, STP, and OSPF in IPv4 and IPv6 networks.
Some new episodes are even fully written, which means fans are in for a huge treat when the next installment officially drops. Poopybutthole, suggesting late 2019 is likely the earliest we're going to see season 4 of Adult Swim's wildly popular series.
Caterpillar Inc. (NYSE:CAT) for the trailing twelve months paying dividend with the payout ratio of 206.01% to its shareholders. Investors look at the Volatility 12m to determine if a company has a low volatility percentage or not over the course of a year.
He missed one game and parts of others but had a breakout showing against Ole Miss with 22 carries for 276 yards and a touchdown. Guice set the single-season school record for rushing yards in a 285-yard effort against Texas A&M in the 2016 season finale.
With almost 300,000 square feet of auto exhibit space, this year's CES is considered the fifth-largest auto show in the country. This year it was Chief Executive Jim Hackett on stage, but he continues what has become a Ford tradition at the event.
More complications followed as intense coughing caused her C-section wound to open and a hematoma was found in her abdomen. Knowing I've got this lovely baby to go home to makes me feel like I don't have to play another match.
Authorities placed the bombs in underground worship halls beneath the church and proceeded to destroy its above-ground building. These regulations grant the Chinese Communist Party increased power over religion , paving the way for escalated persecution.
Cena also announced that he will voice the Baron Draxum character in the network's " Rise of the Teenage Mutant Ninja Turtles ". After each game, a 360-degree scanner will measure each team's mess to determine who kept it the most tidy.
Reaction among advisers at Merrill was mixed, with some welcoming it as "prudent" and others ruing "missed trading opportunities". Merrill Lynch has blocked all of their retail customers from investing in Grayscale's Bitcoin Investment Trust (OTC: GBTC).
The company is showing signs of making a comeback, as competitors are forced to merge and consolidate in order to survive. The industry can be broken down further between mobile gambling and desktop gambling (which includes laptops and PCs).
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