Sunday, 22 April, 2018

Cancer survival 'not affected by faulty BRCA gene'

Having a mutated BRCA gene- as famously carried by Angelina Jolie- dramatically increases the chance a woman will develop breast cancer in her lifetime from 12 per cent to 90 per cent Cancer survival 'not affected by faulty BRCA gene'
Patty Aguilar | 12 January, 2018, 22:50

Therefore, he concluded, "This important topic needs more prospective research, as preventive surgical measures might have an effect on what might be a very long life after a diagnosis of breast cancer at a young age".

The researchers tracked the women a their treatment for more than eight years. When they carry mistakes themselves, the fix isn't made, or it's made improperly.

The study did not look at preventative mastectomies. About 45 percent of women with faulty BRCA2 genes will.

Doctors had found that the star had mutations in BRCA genes which increase a woman's risk of breast cancer by four-to-eightfold. Besides breast cancer, these mutations have been linked to an increased risk of ovarian and prostate cancers. After 10 years, those rates were 73.4 percent and 70.1 percent, respectively.

Women who carry a risky cancer gene have the same survival chances as other women with breast tumours, researchers have found.

This was not affected by the women's body mass index or ethnicity.

This means that breast cancer patients can wait and see how they feel about things and how their health is before they decide whether to have more surgery - for instance, to remove the healthy breast to lower any risk that breast cancer might return in that one. This surgery did not appear to improve their chances of survival at the 10-year mark.

PALB2 - Works similarly to the BRCA genes.

BRCA1 - Led Angelina Jolie to have a double mastectomy because of her risk of breast cancer.

BRCA2 - Mutations prevent DNA from repairing itself properly, leading to breast cancer. A person's cancer risk can vary a lot depending on which mutation they have.

Actor and director Angelina Jolie attends The 23rd Annual Critics' Choice Awards at Barker Hangar on January 11, 2018 in Santa Monica, California.

"Our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment".

Surgery may still be beneficial for patients to reduce their risk in the longer term, such as two to three decades after their initial diagnosis, she said.

The research team, led by the University of Southampton, used data from 2,733 young women in 127 United Kingdom hospitals who had been diagnosed with primary breast cancer before the age of 40.

"Decisions about timing of additional surgery aimed at reducing future second primary-cancer risks should take into account patient prognosis associated with the first malignancy and patient preferences", the authors write.

For this study, researchers followed more than 2,700 women recruited from more than a hundred British hospitals for almost a decade.

Twelve per cent of the women had a BRCA mutation.

However, the researchers noted the results might not translate to older women with a BRCA mutation, as they were not involved in the study and more research would be needed in this area. Approximately 20% to 25% of patients with hereditary breast cancer and 5% to 10% of patients with any type of breast cancer have a BRCA mutation, according to the release.



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